When recombinant DNA technology started early in the ’70s, it was the unknown in front of all us. And the unknown always scares people. The majority worried about experiments performed with viruses as vectors to modify the genome of humans. There was an expectation then that one day we could do what is now called gene therapy. The Asilomar Conference on Recombinant DNA was organized in San Diego to deal with concerns, and immediately a moratorium was established for over a year, until the NIH delivered rules for using this new technology.