Nature Chemistry | The Sceptical Chymist

Educating Excimer: The End of the ‘Cookbook’ Lab

[Joining The Sceptical Chymist is our latest guest blogger, Aaron Finke. A grad student at the University of Illinois, Urbana-Champaign, he works on polyphenylene dendrimers and hyperbranched polymers. You may know Aaron better as Excimer from his posts at Carbon-Based Curiosities.]

I will be focusing most of my energies on these guest-blogging posts to chemical education. This past semester, I had the opportunity to be in charge of a large laboratory course — specifically, the organic chemistry lab course for non-chemistry majors. The “behind-the-scenes” experience I got was an eye-opening one in many ways, from a pedagogical, professional, and personal perspective. I will attempt to recount my experiences and lessons learned here.

A large portion of the students in my lab course were pre-medical and pre-veterinary students, and took it to satisfy the requirements for getting into their respective programs. A majority of the students took this course with the full recognition that it was merely a hurdle for them — a hoop to jump through with no relevance to the future careers to which they are aspiring.

I can’t blame them for having that mentality. The course is an organic chemistry laboratory course, designed to introduce procedures and methods in the synthesis and purification of organic molecules… skills that are mostly irrelevant to those outside of organic chemistry. They learn and perform techniques like extraction, column chromatography, recrystallization, basic organic synthesis, and so on. I use a majority of these techniques every day. But I am an organic chemist. The 500 students in my class are not. It is highly unlikely they will actually use the specific skills implemented in the course, unless they plan on distilling their own whiskey! [Editor’s note: This is illegal in many countries]

The skills students SHOULD be learning in laboratory classes are more general, and, with a “cookbook” chemistry curriculum, are not developed in any capacity. A report which came out June 4, co-authored by the Association of American Medical Colleges (AAMC) and the Howard Hughes Medical Institute (HHMI) and entitled “Scientific Foundations for Future Physicians”, outlines eight core competencies that pre-medical students should demonstrate before entering medical school.

The second competency listed concerns lab courses: “[The student should] demonstrate understanding of the process of scientific inquiry, and explain how scientific knowledge is discovered and validated.” Interestingly, the guidelines indicate only three chemistry-specific goals: gathering primary data for mixtures of compounds, using stoichiometric analysis to determine yield, and, most interestingly, demonstrate a knowledge of instrumentation such as NMR, mass spec, X-ray, etc. These goals, ideally, should be implemented with a focus on discovery, making conclusions, and understanding error.

Most pre-med organic chemistry lab experiments focus on only one of those three things — characterization without application; or synthesis without full characterization — and I dare say few, if any, display a heavy focus on instrumentation. This report acknowledges that advances in medical science and medicinal chemistry rely heavily on modern instrumentation, and yet outdated chemical identification methods are more heavily emphasized in most basic lab courses. When was the last time anyone had to make a semicarbazone derivative of a ketone outside of a lab course? These are secondary or tertiary methods of identification to modern organic chemists. It is enough to know that they exist. But if medical students are to understand the modern literature, they should be taught modern chemical methods. And in their o-chem labs, they are not.

In my next post, I’ll discuss what some chemistry educators are doing to fix the problem of relevancy in lab courses.

[Posted on behalf of Aaron Finke]


  1. Report this comment

    Materials Girl said:

    In my experience, the same lab courses [in the catalog] range from terrible to good depending on the professor & the particular TA you get; I’ve had both competent and useless TAs, as anyone else likely has. The amount of learning really depends ultimately on the student, though – those who just want to get by with a B, can, while those who want to learn more theory, refine more skills, etc. can do just that.

    Chem majors at my school certainly love to complain about premeds ruining the curve in lower-division o-chem classes (mostly the lecture courses, though, since less of them take the labs). ;)

    Finally, welcome to the pack! I believe you’re the first guest contributor whose “real” name has been revealed. Interesting.

  2. Report this comment

    Will said:

    When I took orgo lab, it was a mix between the two. We did boring semicarb derivatives and melting points, but we also got NMR data.

    The orgo lab that I’m TA’ing for is much more focused on NMR, GCMS, etc, so it is nice in the sense that it’s more modern.

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    CMCguy said:

    Org Chem courses and labs (and most other Science classes) can also teach about making connections and solving problems which are valuable. Certainly some of the “hard core” stuff and details are lost on MDs but trust learn enough to appreciate what goes into the drugs they prescribe and maybe even assist them when they read or hear about a drugs MOA, metabolites or other chemical/biochemical that do impact their practice of medicine. At the same time there does need to be efforts made in the courses to coordinate and place real world context to things related to future occupations (such as “this reaction is used to make drug X”) with such associations generally helpful for most people’s understanding.

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    Howard Whitlock said:

    I have four comments:

    (1) Organic chemistry is a major branch of science. It has given to society a host of beneficial products: antibiotics, contraceptives and the world of ethical drugs being a few. It’s a going and growing concern. So we need a course in introductory methods. If we grant that premeds don’t need organic lab the the powers that be should remove it as a premed requirement; the idea that the course should be evaluated as an MD’s tool is an extremely narrow one.

    (2) Extraction of no interest to premeds? Oh? Then we must not need to understand partitioning phenomena, or lipid membrane barriers etc.

    (3) I get so tired of hearing the old “We want to save lives. Why do we have to learn this dumb old …” (Fill in the blanks.) If you want to save lives go into sanitary engineering; If you want to be a doctor learn a little about medicine and related subjects.

    (4) Yeah, we shouldn’t have to run a reaction to be a doctor. We all know that those miraculous powders and infusions we give our patients grow on trees. No further understanding of the basis of our career is necessary.