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A refreshing model: peppermint terpenoids

A refreshing model: peppermint terpenoids

Living cells are typically asymmetric, having tens of thousands different biopolymers (proteins and polynucleotides), but merely <1000 types of small molecules, such as amino acids and lipids. An exception is certain plant cells that harbor members of ~40,000 strong group of low molecular weight terpenoids, often displaying a complex compositional balance essential for plant growth and survival (Aharoni et al, 2005). Understanding the intricacies of biosynthesis and interconversion of such unusual cellular components appears to require the full power of Systems Biology. In a recent paper, Rios-Estepa et al (2008) harness a systems approach, including iterative cycles of mathematical modeling and experimental testing, to help elucidate the metabolic dynamics of the terpenoid universe.  Read more