Archive by category | Nature Methods papers

Top downloads for August ’09

A paper describing a potential new pipeline for structural genomics based on small angle X-ray scattering was far and away the most popular paper of the August issue. It will be very interesting to see what kind of impact it has on the field. While it may not provide high-resolution structures like x-ray crystalography, it is certainly faster and has a higher success rate, both of which are critical parameters for high-throughput pipelines. A paper from Helicos describing new terminator nucleotides for single-molecule next-generation sequencing (or should this be 2nd or 3rd generation?) made it to the #5 spot.  Read more

Top downloads for July ’09

Two Correspondences made the list of top downloads for July coming in at #3 and #4, demonstrating that while this format may not report new methods it does have information of high interest to readers. The two top downloads seem to highlight a high level of interest in assaying single cells and using FRET to examine protein dynamics.  Read more

Top downloads for May ’09

Below I’ve posted the rankings of the six most popular papers published in our May issue based on downloads and page-views during May. The most popular paper by a rather large margin was a paper describing mRNA-Seq analysis of single cells. Regular readers of this blog won’t be surprised by this given the high level of interest that next-generation sequencing papers generally receive.  Read more

Reproducible proteomics

Our June issue, which went live online yesterday, includes an Analysis paper describing the results of a large-scale study to try to get to the root causes of irreproducibility in mass spectrometry-based proteomics. Despite the novel and valuable biological applications made possible by proteomics and the continuing impressive technological advances in mass spectrometry, the technology has been unable to completely shed its reputation of being poorly reproducible.  Read more

Top downloads for March ’09

It’s a new month and time to see how papers published in Nature Methods have been received by our readers. I alway find it fascinating to see how the numbers of downloads compare to our opinion of each paper. I’ve listed the original research papers we published that received the most unique views (HTML) and downloads (PDF) in March in order of popularity and broken them down between papers published in the March issue and papers published in prior months.  Read more

Can doing things differently enhance reproducibility?

Intuitively most of us would agree that standardized conditions in scientific experiments ensure reproducibility. If I know how something was done and exactly replicate the setup and protocol, I should get the same results. The authors of a Perspective in the April issue of Nature Methods argue otherwise when it comes to behavioral experiments done with live animals.  Read more